Multiple Sclerosis: Study Confirms the Involvement of the Intestine in Its Development

In a new study, German researchers identified cellular phenomena in the intestine that may influence the development of multiple sclerosis.

Intestinal Flora
Intestinal Flora

In recent years a lot of research has been done to emphasize and improve the understanding of the intestinal-brain connection and the influence of the intestinal microbiota on brain health and morale in particular.

In addition, because of the important connections with the nervous system, the intestine is suspected of playing an important role in the development and progression of neurodegenerative and/or autoimmune diseases. This is particularly the case with multiple sclerosis, in which the immune system reacts abnormally and attacks myelin, a substance that forms a protective sheath around the nerves.

A team of neurologists at St Josef’s Hospital of the Ruhr-University of Bochum (Germany) has identified a mechanism that may partially explain the influence of the intestine on the development of multiple sclerosis (MS). In a study published in PNAS magazine, the team used a mouse model to demonstrate that a protein called Smad7 mobilized certain immune cells in the intestine, causing inflammation of the central nervous system (CNS). The most pronounced clinical symptoms, similar to MS, appeared in rats with high levels of Smad7 in the T cells present in the intestine. They then migrated to the CNS, where they caused inflammation. In rats genetically modified to be free of Smad7 protein, there was no evidence of MS-like disease.

In a second step, the researchers analyzed tissue samples from the intestines of 27 patients with MS and compared these samples with those from 27 healthy individuals. The comparison showed similar results as in rats: Smad7 signaling protein appeared more frequently in intestinal mucosa samples from MS patients than in samples from healthy individuals.

“For other autoimmune diseases such as Crohn’s and other inflammatory bowel diseases, researchers are already aware that Smad7 offers a promising therapeutic target; our results suggest that the same is true for multiple sclerosis,” says Ingo Kleiter, co-author of the study. “Researchers are increasingly investigating the involvement of the intestine in the development and progression of MS,” added Simon Faissner. So this protein could be a therapeutic target for new treatments aimed at reducing the progression of MS.

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References:

https://www.pnas.org/content/114/40/10719

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